Nanoparticles for drug delivery

Nanoparticles for drug delivery Nanoparticles for drug delivery.pptx 목차 Introduction Tumor? Delivery method Multistage nanoparticle delivery system for deep penetration into tumor tissue Nanoparticle for cancer therapeutics Multistage nanoparticle delivery How to cause the size change? Structure of QDGelNPs Result using QDGelNPs References 본문 Introduction Nowadays, the method of chemotherapy + radiation is widely used because it is more effective for cancer cells than normal cells. However, patient’s quality of life is directly related to the targeting ability of treatment, so that method has some side effects. So finding less toxic agents and choosing a precise delivery system is a task currently important. Regulation of nanoparticles. Size : 10~100nm (EPR effect) Coating PEG polymer Why nanoparticles? 1) It can deliver a larger quantity of drugs with better safety. 2) Easy to attach targeting ligands. 3) It is enough size to deliver multi-drugs. 4) Can regulate releasing of drug particles. 5) Can avoid multidrug resistance through cell-surface protein pump. 본문내용 cause it is more effective for cancer cells than normal cells. However, patient’s quality of life is directly related to the targeting ability of treatment, so that method has some side effects. So finding less toxic agents and choosing a precise delivery system is a task currently important. Introduction Tumor? Regulation of nanoparticles. Size : 10~100nm (EPR effect) Coating PEG polymer Why n 참고문헌 [1] Lisa B-P., et al. Nanoparticle and targeted systems for Cancer therapy. Advanced Drug Delivery Reviews 56, 1649 1659 (2004) [2] Mark E. D., et al. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nature Review Drug Discovery 7, 771-782 (2008) [3] Stephane M., et al. Magnetic nanoparticle design for medical diagnosis and therapy. J. Mater. Chem. 14, 2161-2175 (2004) [4] Gao X., Cui Y., et al. In vivo cancer targeting and imaging with Semiconductor quantum dots. Nature Biotechnology 22, 969-976 (2004) [5] Fabienne D., et al. Paclitaxel-loaded PEGylated PLGA-based nanoparticles: In vitro and in vivo evaluation. Journal of Controlled Release 133, 1117 (2009)