목차
What are embryonic & adult stem cells?
What are the
advantages of adult stem cells, compared to embryonic stem cells?
Where
are they and how are they isolated?
What can we do with the stem
cells?
본문
Stem cell calssification
1.Based upon
location
Embryonic stem cells
Somatic/ adult stem
cells
2.Based upon
function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant
administration
Little engraftment after 3~4 weeks
Host immune system
impaired
Vulnerable to Infection
↓Need brief immuno-repressents
&
high tolerance
3 Co-stimulatory Drugs
본문내용
ls, compared to
embryonic stem cells?
Where are they and how are they isolated?
What can
we do with the stem cells?
Content
What are embryonic & adult stem
cells?
What are the advantages of adult stem cells, compared to embryonic
stem cells?
Where are they and how are they isolated?
What can we do with
the stem cells?
What are Stem Cells?
Stem cell
= Blank
cell
Stem Cell Classification
1. Base
참고문헌
What are
embryonic & adult stem cells?
Thomson et. al; Itskovitz-Eldor, J;
Shapiro, SS; Waknitz, MA; Swiergiel, JJ; Marshall, VS; Jones, JM (November
1998). Blastocysts Embryonic Stem Cell Lines Derived from Human. Science 282
(5391): 11451147. doi:10.1126/science.282.5391.1145. PMID 9804556.
Thomson,
James A.; Zwaka (10). Homologous recombination in human embryonic stem cells.
nature biotechnology 21 (3): 319321. doi:10.1038/nbt788.
http://www.nature.com/nbt/journal/v21/n3/full/nbt788.html. Retrieved 19 August
2011.
Andrews P, Matin M, Bahrami A, Damjanov I, Gokhale P, Draper J (2005).
Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of
the same coin. Biochem Soc Trans 33 (Pt 6): 152630. doi:10.1042/BST20051526.
PMID 16246161.
Martin GR (1980). Teratocarcinomas and mammalian
embryogenesis. Science 209 (4458): 76876. doi:10.1126/science.6250214. PMID
6250214.
Evans M, Kaufman M (1981). Establishment in culture of pluripotent
cells from mouse embryos. Nature 292 (5819): 1546. doi:10.1038/292154a0. PMID
7242681.
Martin G (1981). Isolation of a pluripotent cell line from early
mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc
Natl Acad Sci USA 78 (12): 76348. doi:10.1073/pnas.78.12.7634. PMC 349323. PMID
6950406.www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=349323.
Thomson J, Itskovitz-Eldor J, Shapiro S, Waknitz M, Swiergiel J, Marshall V,
Jones J (1998). Embryonic stem cell lines derived from human blastocysts.
Science 282 (5391): 11457. doi:10.1126/science.282.5391.1145. PMID 9804556.
What are the advantages of adult stem cells, compared to
embryonic stem cells?
Hwang YS 외 5명, Microwell-mediated control of embryoid
body size regulates embryonic stem cell fate via differential expression of
WNT5a and WNT11, Proc Natl Acad Sci USA, 2009
Yang F 외 7명,Combinatorial
extracellular matrices for human embryonic stem cell differentiation in 3D,
Biomacromolecules, 2010
Mitra Lavasani 외 10명, Muscle-derived stem/progenitor
cell dysfunction limits healthspan and lifespan in a murine progeria model,
Nature communications, 2012
Kitai Kim,1,2,4 Paul Lerou,1,4,5 Akiko
Yabuuchi,1,2,4 Claudia Lengerke,1,2,4 Kitwa Ng,1,2,4 Jason West,1,2,4 Andrew
Kirby,6 Mark J. Daly,6 George Q. Daley1,2,3,4*, Histocompatible
Embryonic
November 2007: Human induced pluripotent stem cells: Two
similar papers released by their respective journals prior to formal
publication: in Cell by Kazutosi Takahashi and Shinya Yamanaka, Induction of
pluripotent stem cells from adult human fibroblasts by defined factors“, and in
Science by Junying Yu, et al., from the research group of James Thomson, Induced
pluripotent stem cell lines derived from human somatic cells“: pluripotent stem
cells generated from mature human fibroblasts.
Where are they and how
are they
isolated?
http://www.sumanasinc.com/webcontent/animations/content/stemcells_scnt.html
The New England Journal of Medicine.Volume 349:570-582, August 7, 2003,Number 6
http://www.ldysinger.com/ThM_599d_Beg/06_Stem-Cell/04_NEJM_adut-stem1.htm
Adult
Cells, Reprogrammed To Embryonic Stem Cell Like State, Treat Sickle-Cell Anemia
In Mice
ScienceDaily (Dec. 6, 2007)
PNAS April 29, 2008 vol. 105 no. 17
6332-6337 http://www.pnas.org/content/78/12/7634.short
November 2007:
Human induced pluripotent stem cells: Two similar papers released by their
respective journals prior to formal publication: in Cell by Kazutosi Takahashi
and Shinya Yamanaka, Induction of pluripotent stem cells from adult human
fibroblasts by defined factors“, and in Science by Junying Yu, et al., from the
research group of James Thomson, Induced pluripotent stem cell lines derived
from human somatic cells“: pluripotent stem cells generated from mature human
fibroblasts.
What can we do with the stem cells?
K. J. Godfrey 외 5명,
Review Article Stem cell-based treatments for Type 1 diabetes mellitus:
bone
marrow, embryonic, hepatic, pancreatic and induced pluripotent stem cells,
DIABETICMedicine, 2011
Jong-Hoon Kim 외 10명, Dopamine neurons derived from
embryonic stem cells function in an animal model of Parkinson’s disease, Nature,
2002
www.bcellbio.co.kr
www.bestcell.co.kr
http://www.yonhapnews.co.kr/society/2012/01/12/0706000000AKR20120112068500009.HTML
http://www.hankyung.com/news/app/newsview.php?aid=2010101831951
http://www.edaily.co.kr/news/NewsRead.edy?newsid=02315686599528920&SCD=DH34&DCD=A00710
http://www.cnn.com/2008/HEALTH/12/22/stem.cell.drug.tests/index.html
BYUNG-SOON PARK, MD, PHD,_y KYOUNG AE JANG, MD,y JONG-HYUK SUNG, PHD, et al.
Adipose-Derived Stem Cells and Their Secretory Factors as a Promising Therapy
for Skin Aging. American Society for Dermatologic Surgery.
2008;34:13231326.
Kotaro Yoshimura Æ Katsujiro Sato Æ Noriyuki Aoi, et al.
Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation : Supportive
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